KLF4 is a FOXO target gene that suppresses B cell proliferation
نویسندگان
چکیده
منابع مشابه
Functional Characterization of a FoxO Target Gene
FoxO transcription factors play important roles in many cellular processes, including regulation of lifespan in invertebrates and potentially in vertebrates. Our understanding of FoxO target genes that play a role in lifespan control is incomplete and C. elegans is a useful system in which to approach this problem since it has a single FoxO ortholog (DAF-16) and a relatively short lifespan. Usi...
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Genes that are strongly repressed after B-cell activation are candidates for being inactivated, mutated, or repressed in B-cell malignancies. Krüppel-like factor 4 (Klf4), a gene down-regulated in activated murine B cells, is expressed at low levels in several types of human B-cell lineage lymphomas and leukemias. The human KLF4 gene has been identified as a tumor suppressor gene in colon and g...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2008
ISSN: 0953-8178,1460-2377
DOI: 10.1093/intimm/dxn024